# TB-500 Research References | MD/TB-500

> Complete reference list for TB-500 and thymosin beta-4 research cited on MD/TB-500 — 18 publications, PubMed and DOI links, filterable by year, species, and study type.

## References

[1] Philp D, Kleinman HK. Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide. Ann N Y Acad Sci. 2010;1194:81-86. https://pubmed.ncbi.nlm.nih.gov/20536453/
[2] Goldstein AL, Hannappel E, Kleinman HK. Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005;11(9):421-429. https://pubmed.ncbi.nlm.nih.gov/16099219/
[3] Xu B, Yang M, Li Z, Zhang Y, Jiang Z, Guan S, Jiang D. Thymosin beta4 enhances the healing of medial collateral ligament injury in rat. Regul Pept. 2013;184:1-5. https://pubmed.ncbi.nlm.nih.gov/23523891/
[4] Ehrlich HP, Hazard SW 3rd. Thymosin beta4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts. Ann N Y Acad Sci. 2010;1194:118-124. https://pubmed.ncbi.nlm.nih.gov/20536458/
[5] Srivastava D, Saxena A, DiMaio JM, Bock-Marquette I. Thymosin beta4 is cardioprotective after myocardial infarction. Ann N Y Acad Sci. 2007;1112:161-170. https://pubmed.ncbi.nlm.nih.gov/17600280/
[6] Kleinman HK, Sosne G. Thymosin beta4 Promotes Dermal Healing. Vitam Horm. 2016;102:251-275. https://pubmed.ncbi.nlm.nih.gov/27450738/
[7] Guarnera G, De Rosa A, Camerini R. Thymosin beta-4 and venous ulcers: clinical remarks on a European prospective, randomized study on safety, tolerability, and enhancement on healing. Ann N Y Acad Sci. 2007;1112:403-410. https://pubmed.ncbi.nlm.nih.gov/17495250/
[8] Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD. Doping control analysis of TB-500, a synthetic version of an active region of thymosin beta4, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012;1265:57-69. https://pubmed.ncbi.nlm.nih.gov/23084823/
[9] Ruff D, Crockford D, Girardi G, Zhang Y. A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers. Ann N Y Acad Sci. 2010;1194:223-229. https://pubmed.ncbi.nlm.nih.gov/20536472/
[10] Kim S, Kwon J. Thymosin beta 4 improves dermal burn wound healing via downregulation of receptor of advanced glycation end products in db/db mice. Biochim Biophys Acta. 2014;1840(12):3452-3462. https://pubmed.ncbi.nlm.nih.gov/25230158/
[11] Matsuo K, Akasaki Y, Adachi K, Zhang M, Ishikawa A, Jimi E, Nishihara T, Hosokawa R. Promoting effects of thymosin beta4 on granulation tissue and new bone formation after tooth extraction in rats. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(2):e9-e16. https://pubmed.ncbi.nlm.nih.gov/22732845/
[12] Wang X, Liu L, Qi L, et al. A first-in-human, randomized, double-blind, single- and multiple-dose, phase I study of recombinant human thymosin beta4 in healthy Chinese volunteers. J Cell Mol Med. 2021;25(17):8441-8451. https://pubmed.ncbi.nlm.nih.gov/34346165/
[13] Histological Evaluation of Effect of Thymosin Beta 4 on Wound Healing of Skin. Eur J Dent. 2024;5(3). doi:10.24018/ejdent.2024.5.3.330. https://eu-opensci.org/index.php/ejdent/article/view/13330
[14] Qiu P, Kurpakus Wheater M, Qiu Y, Sosne G. Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J. 2011;25(6):1815-1826. https://pmc.ncbi.nlm.nih.gov/articles/PMC3101037/
[15] Thymosin beta4 released from functionalized self-assembling peptide activates epicardium and enhances repair of infarcted myocardium. Theranostics. 2021;11(13):6214-6228. https://pubmed.ncbi.nlm.nih.gov/33754060/
[16] Sosne G, Qiu P, Kurpakus-Wheater M. Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent. Clin Ophthalmol. 2007;1(3):201-207. https://pmc.ncbi.nlm.nih.gov/articles/PMC2701135/
[17] Cha HJ, Jeong MJ, Kleinman HK. Role of Thymosin beta4 in Tumor Metastasis and Angiogenesis. J Natl Cancer Inst. 2003;95(22):1674-1680. https://pubmed.ncbi.nlm.nih.gov/14625258/
[18] Bjorklund G, Dadar M, Aaseth J, Chirumbolo S. Thymosin beta4: A Multi-Faceted Tissue Repair Stimulating Protein in Heart Injury. Curr Med Chem. 2020;27(37):6294-6305. https://pubmed.ncbi.nlm.nih.gov/31333080/
[11a] Philp D, St-Surin S, Cha HJ, Moon HS, Kleinman HK, Elkin M. Thymosin beta 4 induces hair growth via stem cell migration and differentiation. Ann N Y Acad Sci. 2007;1112:95-103. https://pubmed.ncbi.nlm.nih.gov/17947589/
[11b] Gao X, Liang H, Hou F, Zhang Z, Nuo M, Guo X, Liu D. Thymosin Beta-4 Induces Mouse Hair Growth. PLoS One. 2015;10(6):e0130040. https://pubmed.ncbi.nlm.nih.gov/26083021/
[16b] Bjorklund G, Dadar M, Aaseth J, Chirumbolo S. Thymosin beta4: A Multi-Faceted Tissue Repair Stimulating Protein in Heart Injury. Curr Med Chem. 2020;27(37):6294-6305. https://pubmed.ncbi.nlm.nih.gov/31333080/

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The TB-500 record: Ac-LKKTETQ, amber-phosphor, dumped to stdout from the peer-reviewed literature — no clinic, no prescription, no commercial position.